Ronan+Dolan

Cystic Fibrosis **Description:** Cystic Fibrosis is a autosomal recessive genetic disorder that causes the body to have difficulty regulating sweat, digestive fluids, and mucus. It is caused by a genetic mutation in the CFTR gene. the It can affect many organs and functions from lungs to fertility. **Symptoms:**

**Common Treatments:** Kalydeco- Drug that helps mucus get into the airways so it is easier to cough out Airway Clearance Techniques- Techniques that attempt to loosen up the mucus and clear the airways by coughing and putting pressure on the chest   Inhaled Medications- Used with a nebulizer and get to the airways much faster than other medication because they are inhaled   Antibiotics- Fight infection causing bacteria, given to people with lung infections   **Side Effects:** Some medicines can irritate the lungs and chest even more causing coughing. They can also cause nausea and wheezing. Hair cell loss and hearing damage are side effects of nasal treatments using aminoglycosides. Salt therapy can cause skin irritation. **Prevention and Control:** Because Cystic Fibrosis is a inherited disease there is no prevention except for two carries of the disease to not have kids. However there are many ways to help control the disease. Not smoking is very important in preventing the disease from getting worse. Eating healthy and using airway clearance techniques is also very effective. You must also have all your shots and immunizations. Obviously taking the proper medications controls the disease. **Chromosome 7:** Mutations to the CFTR Gene on Chromosome 7 cause Cystic Fibrosis. gene makes the CFTR protein. The most common mutation happens when there is a deletion of t hree nucleotides. Because of this a person with Cystic Fibrosis loses the amino acid called phenylalanine.
 * Salty skin
 * Lung Infections
 * Coughing
 * Shortness of breathe
 * Wheezing
 * Poor growth/Weight gain
 * Bowel obstruction



**Inheritance of Disease:** In order for Cystic Fibrosis to be passed on to offspring the parents must both be carriers of the disease. This is because it is an autosomal recessive disease. Even if the parents are carriers there is still only a 1 in 4 chance their kid gets the disease and a 50 percent chance he or she is a carrier of Cystic Fibrosis. Parents can get genetic testing to determine if they are carriers of Cystic Fibrosis and to see the chances that their children get it.

**Populations With Predispositions To The Disease:** Cystic Fibrosis is much more common in people of European descent. 1 in 25 of them are carriers of the disease compared to 1 in 65 in blacks or 1 in 90 in asains. The disease itself is 1 in 3,300 in caucasian American and 1 in 15,000 in African American and 1 in 32,000 in Asains. It is equally diagnosed in females and males. **Works Cited:** CFF.org. Cystic Fibrosis Foundation. Web. 10 Feb 2013. . "Cystic Fibrosis Prevention." // webmd.com //. Web MD. Web. 10 Feb 2013. .