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=__What is Marfan Syndrome?__=

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Marfan syndrome is inherited by a connective-tissue disorder transmitted as an autosomal dominant trait. It is worldwide and can be life threatening affecting 1 out of 5,000 Americans. It is normally resulted in mutations from the chromosome 15, encoding glycoprotein fibrillin. It affects the body’s connective tissue which provides strength, support and elasticity to your tendons, cartilage, heart valves, blood vessels, and other major parts of the body. The reason why the tissue lacks protein is due to the abnormal chemical make up which causes problems to the skin, eyes, bones, lungs and nervous system. Although it affects many parts of the body the most threatening is to the aorta, the artery that carries the body from the heart to the rest of the body, what makes it such a threat is that the inner lining of the aorta can be ruptured causing possible death. Surgery is always a required procedure, to replace the ruptured parts of the aorta. =====

__Physical Features__
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 * A chest that sinks in or sticks out
 * Crowded teeth
 * Long arms, legs, fingers and toes
 * Flexible joints
 * Tall thin build
 * Scoliosis, or curvature of the spine.

=__**Causes**__= Marfan's Syndrome is a defect or other words a mutation that you are born with but sometimes not diagnosed with until later. Marfan's Syndrome is inhereted which means the child of a parent who has the syndrome has a fifty chance of being diagnosed.

=** __Symptoms__ **= Symptoms start to change while the person ages. Some people may only have mild symptoms and other may have harsh symptoms. Most symptoms are intial such as Doctors say there is no exact cure but with early realization you can go into extreme management to help identify the gene that is causing the syndrome. There are the right specialist to help __[|treatment program]__ People who get treatment can have the life expectancy of 70 and those who do not get help will live to be about 40. People who have Marfan's Syndrome are treated by a multidisciplinary medical team that includes a geneticist, cardiologist, ophthalmologist, orthopedist and cardiothoracic surgeon. =**__Marfan's Chromosomes__**= Sometimes a new gene defect occurs during the formation of sperm or egg cells. It's possible for two parents without the disease to have a child to have Marfan's Syndrome but it is rare. Unaffected parents have only a 1 in 10,000 chance of having a child with Marfan syndrome. The is about a possible 25% percent of cases are due to a spontaneous mutation at the time of conception.
 * Tall and slender build (anorexia appearance)
 * Unsteady heart beats
 * Flat feet
 * A curved spine
 * Nearsighted



The greatest thing marfan's syndrome effects is the aorta.


Cardiovascular abnormalities are the most life threatening symptoms of Marfan syndrome. The dilated aorta leaves the heart, mitral valve prolapse, tricuspid valve prolapse, enlargements of the proximal pulmonary artery, and a high risk for aortic tear and rupture(aortic dissection).

"Heart Disease and Marfan Syndrome." //WebMD//. Heart Health Center, 2005. Web. Web. 10 Feb. 2013. .

"Learning About Marfan Syndrome." National Institutes of Health, 14 Nov 2012. Web. Web. 10 Feb. 2013. .

"Marfan Syndrome." //Boston Childrens Hospital//. N.p., 2005-2011. Web. Web. 10 Feb. 2013. .