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Wednesday, March 9

  1. page Kaitlyn S edited ... {Symptoms.jpg} Slow or abnormal eye movements Impaired gait, walk, posture and Difficul…
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    {Symptoms.jpg}
    Slow or abnormal eye movements
    Impaired gait,walk, posture and
    Difficulty with physical production of speech or swallowing
    Cognitive Disorders Associated with Huntington's:
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  2. page Kaitlyn S edited ... DEFINITION: Huntington's Disease is a rare genetic disease that is inherited that causes the p…
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    DEFINITION: Huntington's Disease is a rare genetic disease that is inherited that causes the progressive degeneration of nerve cells in the brain.
    Huntington's Disease is an autosomal dominant disorder that has a extensive impact on functional abilities including movement, cognitive and psychiatric.
    ...
    before a person;sperson's twenties, it is called
    {HDvsNORM.jpg} Comparison: (left) a brain affected by Huntington's Disease and a normal brain (right)
    HUNTINGTON'S DISEASE: Inheritance, Which Chromosome and People Affected.
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  3. page Kaitlyn S edited ... People Affected: The disease affects an estimated 3 to 7 per 100,000 people of European ancest…
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    People Affected: The disease affects an estimated 3 to 7 per 100,000 people of European ancestry and is less common in people of Japanese, Chinese and African decent.
    SYMPTOMS: The initial symptoms for Huntington's Disease greatly varies depending on the affected person. Some disorders that are associated with Huntington's are more dominant than others and some disorders have a great impact on the affected person.
    Movement Disorders Associated with Huntington's: Movement Disorders in Huntington's are both involuntary movements and impairment in voluntary movements.
    Impairments in voluntary movements will affect a person's ability to work,communicate, perform daily activities and stay independent.
    Movement Disorders Associated with Huntington's: Movement Disorders in Huntington's are both involuntary movements and impairment in voluntary movements.
    Involuntary jerking or writhing movements
    Muscle problems - more specifically rigidity or muscle contracture
    ...
    Other disorders associated with Huntington's are obsessive-compulsive disorder( recurrent intrusive thoughts and behaviors), Mania (elevated mood, over-activity, impulsive behavior and inflated self-esteem) and Bipolar disorder (episodes of depression and mania)
    SYMPTOMS OF JUVENILE HUNTINGTON'S DISEASE: Symptoms will slightly differ from onset in thirties or forties.
    Behavioral Changes: {PSHD.jpg}
    Loss of previously learned information academic or physical skills
    Rapid or significant drop in overall school performance
    ...
    Levetiracetam may cause nausea, stomach upset and mood swings
    Clonazepam may worsen cognitive side effects of Huntington's and cause drowsiness ans well as a high risk of dependence and abuse
    MEDICATIONS FOR PSYCHIATRIC DISORDERS:
    Citalopram (Celexa, Lexapro), fluoxetine (Prozac, Sarafem) and sertraline (Zoloft) may have side effects in treating obsessive-compulsive disorder such as nausea, diarrhea, drowsiness and low blood pressure
    Quetiapine (Seroquel), risperidone (Risperdal) and olanzapine (Zyprexa) may suppress violent outbursts, agitation and symptoms of mood disorders or psychosis but may cause different movement disorders
    Valproate (Depacon), carbamazepine (Carbatrol, Epitol, Equetro) and Iamotrigine (Lamictal) can help prevent the mood swings associated with bipolar disorder
    Common side effects include weight gain, tremor and gastrointestinal problems
    Psychotherapy, speech therapy, and physical therapy and occupational therapy can also manage symptoms of Huntington's
    MANAGING COGNITIVE AND PSYCHIATRIC DISORDERS: Creating an environment to help avoid stressors and manage cognitive and behavioral challenges...
    Using calendars and schedules to help keep regular routine {Treatment.jpg}
    Initialing task with reminders or assistance
    Prioritizing or organizing work or activities
    Breaking down tasks into manageable steps
    Creating a calm, simple and structures environment (as much as possible)
    Identifying and avoiding stressors that can trigger outbursts, irritability, depression or other problems
    Providing opportunities for the person to maintain social interactions and friendships
    PREVENTION:
    People with a known family history may consider genetic testing. An at-risk parent who is considering genetic testing should see an genetic counselor who will disuses the risk of a positive test result. Other choices could be whether to have children or consider alternatives
    Work Cited
    Genetic Science Learning Center. "Huntington's Disease." Learn.Genetics 9 March 2016 <http://learn.genetics.utah.edu/content/disorders/singlegene/hunt/>
    "Huntington Disease." Genetics Home Reference. Web. 09 Mar. 2016. <https://ghr.nlm.nih.gov/condition/huntington-disease>
    "Huntington's Disease." - Mayo Clinic. Web. 09 Mar. 2016. <http://www.mayoclinic.org/diseases-conditions/huntingtons-disease/basics/definition/con-20030685>
    Pic 2 Fly." Huntington's Disease Pedigree Chart Submited Images. Web. 09 Mar. 2016. <http://www.pic2fly.com/Huntington's Disease Pedigree Chart.html>
    Hdroster - About HD The Brain and HD." Hdroster - About HD The Brain and HD. Web. 09 Mar. 2016. <http://hdroster.iu.edu/AboutHD/brainAndHD.asp>
    Make a Move Against Huntington'sDisease (HD) Chorea." XENAZINE® (tetrabenazine) Tablets. Web. 09 Mar. 2016. <https://www.xenazineusa.com/HCP/AboutHDChorea>
    Huntington's Disease Advocacy Center - HDAC Article: - A Review of the Treatment Options for HD Symptoms." Huntington's Disease Advocacy Center - HDAC Article: - A Review of the Treatment Options for HD Symptoms. Web. 09 Mar. 2016. <http://www.hdac.org/features/article.php?p_articleNumber=258>

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  7. page Kaitlyn S edited ... HUNTINGTON'S DISEASE: Inheritance, Which Chromosome and People Affected. Inheritance: Hunting…
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    HUNTINGTON'S DISEASE: Inheritance, Which Chromosome and People Affected.
    Inheritance: Huntington's Disease is an autosomal dominant disorder, which means that only one copy of the defective gene is needed to inherit the disease. This happens when a parent passes on the defective copy of the gene instead of the healthy copy. Because of this, a child has a 50-50 chance of inheriting the disease.
    ...
    the disease.
    People

    People
    Affected: The
    ...
    African decent.
    SYMPTOMS: The initial symptoms for Huntington's Disease greatly varies depending on the affected person. Some disorders that are associated with Huntington's are more dominant than others and some disorders have a great impact on the affected person.
    Movement Disorders Associated with Huntington's: Movement Disorders in Huntington's are both involuntary movements and impairment in voluntary movements.
    ...
    Frequent thoughts of death and suicide
    Other disorders associated with Huntington's are obsessive-compulsive disorder( recurrent intrusive thoughts and behaviors), Mania (elevated mood, over-activity, impulsive behavior and inflated self-esteem) and Bipolar disorder (episodes of depression and mania)
    ...
    differ from Onsetonset in thirties
    Behavioral Changes:
    Loss of previously learned information academic or physical skills
    ...
    Seizures
    TREATMENTS AND SIDE EFFECTS:
    TREATMENTS: Medicine can be offered in order to manage symptoms but treatments cannot prevent the progression of the disease. While the treatments will be changed based on the progression of the disease some drug will manage symptoms but result in side effects that may worsen other symptoms.
    DRUGS FOR MOVEMENT DISORDERS:
    Tetrabenazine (Xenazine) suppresses the involuntary jerking and writhing movements
    Possible side effects include drowsiness, nausea, restlessness and a serious risk of worsening or triggering depression or other psychiatric conditions.
    Haloperidol (Haldol) and chlorpromazine have a side effect of suppressing movements
    May worsen involuntary contractions and muscle rigidity
    Risperidone (Risperdal) and quetiapine (Seroquel) may help suppress movement disorders but should be used cautiously as it can worsen other symptoms
    Amantadine, levetiracetam (Keppra) and clonazepam (Klonopin) may also help with the movement disorders associated with Huntington.
    Amantadine can worsen cognitive effects of Huntington's in high doses and may cause leg swelling and skin discoloration
    Levetiracetam may cause nausea, stomach upset and mood swings
    Clonazepam may worsen cognitive side effects of Huntington's and cause drowsiness ans well as a high risk of dependence and abuse

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  8. page Kaitlyn S edited Huntington's Disease Kaitlyn Savage Definition: DEFINITION: Huntington's Disease Huntington's…
    Huntington's Disease
    Kaitlyn Savage
    Definition:DEFINITION: Huntington's Disease
    Huntington's Disease is an autosomal dominant disorder that has a extensive impact on functional abilities including movement, cognitive and psychiatric.
    ...
    Huntington's Disease.
    {HDvsNORM.jpg} Comparison: (left) a brain affected by Huntington's Disease and a normal brain (right)
    HUNTINGTON'S DISEASE: Inheritance, Which Chromosome and People Affected.
    Inheritance: Huntington's Disease is an autosomal dominant disorder, which means that only one copy of the defective gene is needed to inherit the disease. This happens when a parent passes on the defective copy of the gene instead of the healthy copy. Because of this, a child has a 50-50 chance of inheriting the disease.
    Which Chromosome: Huntington's Disease is caused by a mutation on a gene (HTT gene) in chromosome 4. The HTT gene provides instructions on making the protein Huntington {chromosome4.jpg} which plays an important role in nerve cells in the brain. The mutation involves a DNA segment (CAG trinucleotide repeat) that is made up of cytosine, adenine and guanine. Normally this segment is repeated 10-35 times but when the mutation occurs repeated 36 to more than 120 times. People of 36-39 CAG segments might or might not develop signs or symptoms of the disease but people with a CAG segment repeated 40 or more times, almost leads to a development in the disease.
    People Affected: The disease affects an estimated 3 to 7 per 100,000 people of European ancestry and is less common in people of Japanese, Chinese and African decent.
    SYMPTOMS: The initial symptoms for Huntington's Disease greatly varies depending on the affected person. Some disorders that are associated with Huntington's are more dominant than others and some disorders have a great impact on the affected person.
    Movement Disorders Associated with Huntington's: Movement Disorders in Huntington's are both involuntary movements and impairment in voluntary movements.
    Impairments in voluntary movements will affect a person's ability to work,communicate, perform daily activities and stay independent.
    Involuntary jerking or writhing movements
    Muscle problems - more specifically rigidity or muscle contracture
    {Symptoms.jpg}
    Slow or abnormal eye movements
    Impaired gait, posture and balance
    Difficulty with physical production of speech or swallowing
    Cognitive Disorders Associated with Huntington's:
    Difficult organizing, prioritizing or focusing on tasks
    Lack of impulse - result in outbursts, acting without thinking
    Slowness in processing thoughts or communicating words
    Difficulty in learning new information
    Psychiatric Disorders: While depression and weight loss are the most common due to injury of the brain and changes in brain function others include...
    Feeling irritability, sadness or apathy
    Social withdrawal
    Fatigue and loss of energy
    Frequent thoughts of death and suicide
    Other disorders associated with Huntington's are obsessive-compulsive disorder( recurrent intrusive thoughts and behaviors), Mania (elevated mood, over-activity, impulsive behavior and inflated self-esteem) and Bipolar disorder (episodes of depression and mania)
    SYMPTOMS OF JUVENILE HUNTINGTON'S DISEASE: Symptoms will slightly differ from Onset in thirties or forties.
    Behavioral Changes:
    Loss of previously learned information academic or physical skills
    Rapid or significant drop in overall school performance
    Behavioral problems
    Physical Changes:
    Contracted and rigid muscles that affect walking
    Changes in fine motor skills like handwriting
    Tremors or slight involuntary movements
    Seizures
    TREATMENTS AND SIDE EFFECTS:

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